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Solution structure of the mithramycin dimer-DNA complex
- Source :
- Biochemistry. July 6, 1993, Vol. 32 Issue 26, p6588, 17 p.
- Publication Year :
- 1993
-
Abstract
- Techniques involving NMR-molecular dynamics and relaxation matrix refinement were utilised in the structure analysis of complexes produced from Mg2+-coordinated mithramycin dimer binding to self-complementary d(T-G-G-C-C-A) and d(T-C-G-C-G-A) duplexes. The molecular structure of the mithramycin dimer d(T-C-G-C-G-A) reveals a two-fold center of symmetry. The aglycon C-8 hydroxyl oxygens are hydrogen bonded to guanine amino protons in the complex due to the positioning of divalent cation coordinated glycons, opposite the central (G3-C4). (G3-C4) segment.
- Subjects :
- Plicamycin -- Usage
DNA -- Research
Biological sciences
Chemistry
Subjects
Details
- ISSN :
- 00062960
- Volume :
- 32
- Issue :
- 26
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.14238966