Kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-88204E

The inhibitory activity of Bis (heteroaryl) piperazine U-88204 E on HIV-1 reverse transcriptase (RT) is analogous to that of AZT, ddI, ddC is useful in the treatment of AIDS patients. Thus, there is a great need for research involving RT inhibitors. U-88204E exhibits antiviral activity at nontoxic doses in the HIV-1 populated lymphocytes in cultured tissues.