Global changes in STAT target selection and transcription regulation upon interferon treatments

Authors :: Hartman, Stephen E.
Bertone, Paul
Nath, Anjali K.
Royce, Thomas E.
Weissman, Sherman
Snyder, Michael
Source :: Genes & Development. Dec 15, 2005, Vol. 19 Issue 24, p2953, 16 p.
Publication Year :: 2005
Abstract: The regions of human chromosome 22 bound by Single Transducers and Activators of Transcription (STAT)1 and STAT2 in interferon-treated cells are identified using chromatin immunoprecipitation and DNA microarray analysis. Results demonstrate that the DNA-binding behavior of STAT1 homodimers is not conserved between the different interferon treatment conditions.

Subjects :: Transducers -- Research
Human chromosomes -- Research
DNA-ligand interactions -- Research
Genetic research
Biological sciences

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