Zinc-Thiolate complexes of the bis(pyrazolyl)(thiomidazolyl)hydroborate tripods for the modeling of thiolate alkylating enzymes

The new tripod ligands bis(pyrazolyl)(3-tert-butyl-2-thioimidazol-1-yl)hydroborate (L(super 1)) and bis(pyrazolyl)(3-isopropyl-2-thioimidazol-1-yl)hydroborate (L(super 2)), together with zinc nitrate or zinc chloride and the corresponding thiolates, have yielded a total of 17 zinc-thiolate complexes. Hydroborate ligands L(super 1) and L(super 2) have enabled a further step in systematic investigation on the modeling of biological thiolate alkylations by zinc enzymes.