Segmental duplications and gene conversion: Human luteinizing hormone/chorionic gonadotropin beta gene cluster

The diversity and linkage disequilibrium (LD) patterns of duplicons and the role of gene conversion in shaping them have been poorly studied and therefore to put some light on these issues, a re-sequencing is done on the human Luteinizing Harmone/Chorionic Gonadotropin B(LHB/CGB) cluster of three population samples (Estonians, Mandenka, and Han). This highlighted an important role of gene conversion in spreading polymorphisms among duplicon copies and generating LD around them.