Endogenous angiotensin II modulates the effect of atrial natriuretic peptide on extracellular fluid preparation

The effect of endogenous angiotensin II on the increase in hematocrit induced by atrial natriuretic peptide (ANP) was examined on nephrectomized rats. Endogenous angiotensin II modulated the effect of ANP on vascular permeability. This was attributed to the supression of angiotensin II generation and antagonism of its receptors which abolishes the effect of ANP on hematocrit. The result suggests a possible role for tissue renin-angiotensin interaction in controlling endogenous ANP on transcapillary shift and formation of edema.