Effects of ET-1 on water and chloride transport in cortical collecting ducts of the rat

Authors :: Tomita, Kimio
Nonoguchi, Hiroshi
Terada, Yoshio
Marumo, Fumiaki
Source :: The American Journal of Physiology. April, 1993, Vol. 264 Issue 4, pF690, 7 p.
Publication Year :: 1993
Abstract: The effects of endothelin-1 (ET-1) on water and electrolyte transport were studied in rat kidney collecting ducts (CCD). ET-1 inhibited arginine vasopressin-dependent fluid and chloride absorption, potential difference and osmotic water permeability. This demonstrates ET-1 inhibition of vasopressin-induced water and chloride reabsorption and suggests a direct function of endothelin on rat CCD.

Subjects :: Endothelin -- Physiological aspects
Chloride channels -- Physiological aspects
Permeability -- Physiological aspects
Water -- Ion exchange process
Kidneys -- Physiological aspects
Biological sciences

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