Natriuretic peptides inhibit mesangial cell production of endothelin induced by arginine vasopressin

Authors :: Kohno, Masakazu
Horio, Takeshi
Ikeda, Miwako
Yokokawa, Koji
Fukui, Toshiki
Yasunari, Kenichi
Murakawa, Koh-Ichi
Kurihara, Naotsugu
Takeda, Tadanao
Source :: The American Journal of Physiology. April, 1993, Vol. 264 Issue 4, pF678, 6 p.
Publication Year :: 1993
Abstract: The effects of natriuretic peptides (NP) on the secretion of endothelin-1 (E-1) was studied in the mesangial cells of rat kidney glomerulus. Atrial NP and brain NP inhibits excessive excretion of E1 on contraction of mesangial cells and glomerular microcirculation by induction of ET-1 secretion by arginine vasopressin. C-type NP also inhibited EP-1 secretion to a lesser degree compared to ANP and BNP.

Subjects :: Natriuretic peptides -- Physiological aspects
Cell proliferation -- Physiological aspects
Arginine -- Physiological aspects
Endothelin -- Physiological aspects
Peptides -- Physiological aspects
Biological sciences

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