Muscle contraction and inward current induced by silver and effect of Ca2+ channel blockers

The effect of Ca+ channel blockers on muscular contraction and silver-induced current was examined by observing specimen toe and anterior tibialis muscles. It was shown that exposure to nifedipine resulted to inhibited phasic contraction although with retained tone. The calcium channel blockers also reversibly inhibited the influx of current. These findings implied that the regulation of Ag+-induced phasic contraction was due to L-type Ca+ channels at the T-tubular membrane that show varied sensitivities to dihydropyridine.