Beta-arrestin and arrestin are recognized by autoantibodies in sera from multiple sclerosis patients

Authors :: Ohguro, Hiroshi
Chiba, Susumu
Igarashi, Yasuo
Matsumoto, Hiroyuki
Akino, Toyoaki
Palczewski, Krzysztof
Source :: Proceedings of the National Academy of Sciences of the United States. April 15, 1993, Vol. 90 Issue 8, p3241, 5 p.
Publication Year :: 1993
Abstract: The presence of autoantibodies in sera of 8 of 14 patients with multiple sclerosis (MS) to brain and retinal soluble antigens was described. The autoantibodies were identified as beta-arrestin 1 and arrestin, respectively. In two patients with MS, serum antibody titers during relapse were higher than found during remission. The recognition sites for antibodies in sera of MS patients was located at a dominant immunogenic site on arrestin located in the C-terminal region of the molecule.

Subjects :: Autoantibodies -- Research
Multiple sclerosis -- Research
Science and technology

ISSN :: 00278424
Volume :: 90
Issue :: 8
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.14056030

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