Exogenous cGMP prevents decrease in diuresis and natriuresis induced by inhibition of NO synthesis

A cyclic guanosine monophosphate (cGMP) analogue was utilized in the investigation of the modulation of the renal parameter alterations brought about by inhibition of nitric oxide synthase with N(sup G)-nitro-L-arginine methyl ester (L-NAME). The cGMP analogue was able to suppress L-NAME-induced changes in mean arterial pressure and renal parameters. This suggests that L-NAME inhibition is mediated via reduction of cGMP levels as administration ofits analogue reversed the observed effects.