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Synthesis of genotoxic heterocyclic amines Trp-P-1 and Trp-P-2
- Source :
- Journal of Organic Chemistry. Oct 23, 1992, Vol. 57 Issue 22, p5917, 5 p.
- Publication Year :
- 1992
-
Abstract
- The synthesis of the 3-amino-1,4-dimethyl and 3-amino-1-methyl derivatives of 5H-pyrido(4,3-b)indole (Trp-P-1 and Trp-P-2) proceeds through the thermal electrocyclic reaction of the 1-azahexa-1,3,5-triene system involving the indole (b) bond. N-(benzenesulfonyl)indole provides the 2-vinylindole substrates via a four-step sequence. Trp-P-1 and Trp-P-2 are genotoxic heterocyclic amines produced by the overcooking of protein-containing food.
Details
- ISSN :
- 00223263
- Volume :
- 57
- Issue :
- 22
- Database :
- Gale General OneFile
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.14019162