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Engineered biosynthesis of aklanonic acid analogues

Authors :
Taek Soon Lee
Khosla, Chaitan
Yi Tang
Source :
Journal of the American Chemical Society. Sept 7, 2005, Vol. 127 Issue 35, p12254, 9 p.
Publication Year :
2005

Abstract

Aklanonic acid, an anthraquinone natural product, is a common advanced intermediate in the biosynthesis of several antitumor polyketide antibiotics, including doxorubicin and aclacinomycin A. A number of improved analogues of therapeutically promising polyketides are prepared by synthetic and biosynthetic means.

Subjects

Subjects :
Anthraquinones -- Chemical properties
Anthraquinones -- Structure
Biosynthesis -- Research
Polyketides -- Chemical properties
Antibiotics -- Chemical properties
Chemistry

Details

Language :
English
ISSN :
00027863
Volume :
127
Issue :
35
Database :
Gale General OneFile
Journal :
Journal of the American Chemical Society
Publication Type :
Academic Journal
Accession number :
edsgcl.139859711

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