Nitric oxide mediates the cytokine-induced inhibition of insulin secretion by human islets of Langerhans

Authors :: Corbett, John A.
Sweetland, Michael A.
Jin Lin Wang
Lancaster, Jack R., Jr.
McDaniel, Michael L.
Source :: Proceedings of the National Academy of Sciences of the United States. March 1, 1993, Vol. 90 Issue 5, p1731, 5 p.
Publication Year :: 1993
Abstract: An investigation was conducted to determine the roles of cytokines and nitric oxide in the destruction of islet beta-cells associated with insulin-dependent diabetes mellitus. The results showed that cytokines inhibit insulin secretion by beta cells in a concentration-dependent manner. Nitric oxide appears to be the mediator of this cytokine-induced inhibition of insulin.

Subjects :: Nitric oxide -- Physiological aspects
Cytokines -- Physiological aspects
Type 1 diabetes -- Development and progression
Pancreatic beta cells -- Physiological aspects
Science and technology

ISSN :: 00278424
Volume :: 90
Issue :: 5
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.13982168

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