Catalytic conjugate additions of carbonyl anions under neutral aqueous conditions

Authors :: Myers, Michael C.
Bharadwaj, Ashwin R.
Milgram, Benjamin C.
Scheidt, Karl A.
Source :: Journal of the American Chemical Society. Oct 26, 2005, Vol. 127 Issue 42, 14675-14680
Publication Year :: 2005
Abstract: A robust catalytic carbonyl anion reaction that is fully operative over a broad range of pH values is developed. Under neutral aqueous conditions, the combination of alpha-keto carboxylates and thiazolium salts produces reactive carbonyl nucleophiles that readily undergo conjugate additions to versatile beta-substituted unsaturated 2-acyl imidazoles.

Subjects :: Aqueous solution reactions -- Analysis
Carbonyl compounds -- Chemical properties
Anions -- Chemical properties
Chemistry

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