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The monoclonal CD4 antibody M-T413 inhibits cellular infection with human immunodeficiency virus after viral attachment to the cell membrane: an approachto postexposure prophylaxis
- Source :
- Proceedings of the National Academy of Sciences of the United States. Nov 15, 1992, Vol. 89 Issue 22, p10792, 5 p.
- Publication Year :
- 1992
-
Abstract
- A study was done to determine the period during whichthe human immunodeficiency virus (HIV) remains sensitive to neutralization after initial binding with cellular CD4 receptor. The aim was to identify the most effective infection inhibitors after HIV binding with the cell membrane has occurred. The results showed that the CD4 monoclonal antibody M-T413 can prevent HIV infection in vitro even as late as 30-120 min after cell contact with the virus. The implications for post-exposure prophylaxis in situations such as occupational exposure and mother-to-infant transmission were discussed.
- Subjects :
- HIV infection -- Prevention
HIV (Viruses)
Science and technology
Subjects
Details
- ISSN :
- 00278424
- Volume :
- 89
- Issue :
- 22
- Database :
- Gale General OneFile
- Journal :
- Proceedings of the National Academy of Sciences of the United States
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.13857380