Human monoclonal Fab fragments derived from a combinatorial library bind to respiratory syncytial virus F glycoprotein and neutralize infectivity

Authors :: Barbas, Carlos F., III
Crowe, James E., Jr.
Cababa, Doug
Jones, Terri M.
Zebedee, Suzanne L.
Murphy, Brian R.
Chanock, Robert M.
Burton, Dennis R.
Source :: Proceedings of the National Academy of Sciences of the United States. Nov 1, 1992, Vol. 89 Issue 21, p10164, 5 p.
Publication Year :: 1992
Abstract: A combinatorial antibody library wasscreened for Fab fragments for the cross-reactive F glycoprotein of respiratorysyncytial virus (RSV). The antibody library yielded 30 clones of which 28 showed clear reactivity with the F glycoprotein. One of these neutralized a wide range of virus isolates at high efficiency. These human Fab fragments willbe useful for the care and treatment of RSV infections of the lower respiratorytract.

Subjects :: Respiratory syncytial virus -- Research
Respiratory tract infections -- Care and treatment
Antibodies -- Health aspects
Science and technology

ISSN :: 00278424
Volume :: 89
Issue :: 21
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.13856446

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