Identification of a previously unknown human collagen chain, alpha-1(XV), characterized by extensive interruptions in the triple-helical region

Authors :: Myers, Jeanne C.
Kivirikko, Sirpa
Gordon, Marion K.
Dion, Arnold S.
Pihlajeniemi, Taina
Source :: Proceedings of the National Academy of Sciences of the United States. Nov 1, 1992, Vol. 89 Issue 21, p10144, 5 p.
Publication Year :: 1992
Abstract: A human placenta cDNA library yielded a clone, termed PF19, which encoded a previously unknown collagen chain. Sequence analysis showed that PF19 contains an insert which codes for a protein of 709 residues including a NH2-terminal signal sequence. Homology searches indicated that the NH2-terminal domain is collagenous while the COOH-terminal domain is noncollagenous. However, the collagenous sequences are interrupted by sequences which may function in glycosylation. It is proposed that this polypeptide be named the alpha-1 chain of type XV collagen.

Subjects :: Collagen -- Analysis
Polypeptides -- Identification and classification
Glycosylation -- Physiological aspects
Science and technology

ISSN :: 00278424
Volume :: 89
Issue :: 21
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.13856438

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