Symmetry in the mechanism of bacteriophage lambda integrative recombination

Authors :: Burgin, Alex B., Jr.
Nash, Howard A.
Source :: Proceedings of the National Academy of Sciences of the United States. Oct 15, 1992, Vol. 89 Issue 20, p9642, 5 p.
Publication Year :: 1992
Abstract: A study was done on the symmetry in the mechanism of bacteriophage lambda integrative recombination. Results have shown that a nucleophile from the recombinase Int attacks the phosphodiesterase backbone during both top- and bottom-strand exchange events in the two attachment sites for integrative recombination. Both phosphodiesters proceed through a covalent protein-DNA intermediate during strand exchange.

Subjects :: Bacteriophage lambda -- Genetic aspects
Genetic recombination -- Research
DNA topoisomerase I -- Research
Science and technology

ISSN :: 00278424
Volume :: 89
Issue :: 20
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.13849890

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