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Activation of expression of genes coding for extracellular matrix proteins in Tat-producing glioblastoma cells
- Source :
- Proceedings of the National Academy of Sciences of the United States. Oct 15, 1992, Vol. 89 Issue 20, p9617, 5 p.
- Publication Year :
- 1992
-
Abstract
- A study was done on the activation of expression of genes coding for extracellular matrix proteins in Tat-producing glioblastoma cells. It was shown that the presence of HIV-1 regulatory protein in Tat is associated with a significant induction in the expression of certain protein components of the extracellular matrix in glial-derived cells. The induction is also seen at the level of protein synthesis and the presence of Tat results in increased transcription of fibronectin and alpha1 type 1 collagen promoters.
Details
- ISSN :
- 00278424
- Volume :
- 89
- Issue :
- 20
- Database :
- Gale General OneFile
- Journal :
- Proceedings of the National Academy of Sciences of the United States
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.13849880