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Elucidating the substrate specificity and condensation domain activity of FkbP, the FK520 pipecolate-incorporating enzyme
- Source :
- Biochemistry. April 26, 2005, Vol. 44 Issue 16, 5993-6002
- Publication Year :
- 2005
-
Abstract
- The expression and purification of recombinant FkbP from the FK520 biosynthetic pathway is reported. The observations suggest that the adenylation domain of FkbP serves as the primary selectivity filter for pipecolate incorporation.
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 44
- Issue :
- 16
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.136425293