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NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry
- Source :
- Cell. July 15, 2005, Vol. 122 Issue 1, p45, 13 p.
- Publication Year :
- 2005
-
Abstract
- The NIPA (nuclear interaction partner of ALK) is identified as a human F-box-containing protein that defines an SCF-type E3 ligase (SCF[super NIPA]) controlling mitotic entry. Assembly of this SCF complex is found to be regulated by cell-cycle-dependent phosphorylation of NIPA, which restricts substrate ubiquitination activity to interphase.
Details
- Language :
- English
- ISSN :
- 00928674
- Volume :
- 122
- Issue :
- 1
- Database :
- Gale General OneFile
- Journal :
- Cell
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.135803931