Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis

Multiple sclerosis (MS) is thought to be an autoimmune disease mediated by T lymphocytes that recognize myelin components of the central nervous system. In a 1 -year double-blind study, 30 individuals with relapsing-remitting, MS received daily capsules of bovine myelin or a control protein to determine the effect of oral tolerization to myelin antigens on the disease. Six of 15 individuals in the myelin-treated group had at least one major exacerbation; 12 of 15 had an attack in the control group. T cells reactive with myelin basic protein were reduced in the myelin-treated group. No toxicity or side effects were noted. Although conclusions about efficacy cannot be drawn from these data, they open an area of investigation for MS and other autoimmune diseases.
Multiple sclerosis is an inflammatory disease of the centtal nervous system (CNS) of presumed autoimmune etiology[1]. Because of its inflammatory nature and evidence for immune activation both within the CNS [...]