Identification of Flt(super 3+) lympho-myeloid stem cells lacking erythro-megakaryocytic potential: A revised road map for adult blood lineage commitment

A study conducted presents an evidence for a population of cells, which although sustaining a high proliferative and combined lympho-myeloid differentiation potential, have lost the ability to adopt erythroid and megakaryocyte lineage fates. It is shown that cells in the Lin(super -1)Sca-1(super +1)-kit(super +1) hematopoietic stem cell (HSC) compartment coexpressing high levels of the tyrosine kinase receptor Flt3 sustains granulocyte, monocyte, and B and T cell potentials.