Copper- and ligand-free sonogashira reaction catalyzed by Pd(0) nanoparticles at ambient conditions under ultrasound irradiation

The sonogashira reaction proceeds at ambient temperature in acetone or room temperature ionic liquid, 1, 3-di-n butylimidazolium tetrafluoroborate ([bbim]BF4), as solvent under ultrasound irradiation to give enhanced reaction rates, excellent chemoselectivity, and high yields. The formation of stable, crystalline, and polydispersed Pd(0) nanoparticles as catalyst for the reaction is shown in the analysis.