Self-association energies of an intact, full-length nuclear receptor: The B-isoform of human progesterone receptor dimerizes in the micromolar range

A quantitative analysis of progesterone receptor (PR)-B self-association energetics is conducted. The studies highlight questions about the relative roles of monomer and dimer in PR-dependent biological function and may additionally offer insight into the mechanisms by which closely related steroid receptors generate transcriptional diversity.