Cysteine residues in the human cannabinoid receptor: Only C257 and C264 are required for a functional receptor, and steric bulk at C386 impairs antagonist SR141716A binding

Authors :: Fay, Jonathan F.
Dunham, Thomas D.
Farrens, David L.
Source :: Biochemistry. June 21, 2005, Vol. 44 Issue 24, p8757, 14 p.
Publication Year :: 2005
Abstract: All but two out of 13 cysteine residues in CB1 (C257 and C264) can be replaced with alaniens and still yield a functionally active reporter. It is demonstrated that the substituted cysteine accessibility method can be carried out to study the structure and function of the CB1 receptor.

Subjects :: Biochemistry -- Research
Cannabinoids -- Research
Cysteine -- Research
Biological sciences
Chemistry

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