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β-cell dysfunction, insulin sensitivity, and glycosuria precede diabetes in hepatocyte nuclear factor-1α mutation carriers

Authors :
Stride, Amanda
Ellard, Sian
Clark, Penny
Shakespeare, Lynette
Salzmann, Maurice
Shepherd, Maggie
Hattersley, Andrew T.
Source :
Diabetes Care. July 2005, Vol. 28 Issue 7, p1751, 6 p.
Publication Year :
2005

Abstract

OBJECTIVE--Patients with diabetes due to hepatocyte nuclear factor (HNF)-1α mutations have β-cell deficiency, insulin sensitivity, altered proinsulin levels, and a low renal threshold for glucose. It is uncertain how many [...]

Details

Language :
English
ISSN :
01495992
Volume :
28
Issue :
7
Database :
Gale General OneFile
Journal :
Diabetes Care
Publication Type :
Periodical
Accession number :
edsgcl.134209995