Darwin's finch beaks, Bmp4, and the developmental origins of novelty

The role of growth factor Bmp4 during the evolution in the beak morphology of Darwin's finches on Galapagos Islands is discussed. The shifts in the heterochronic-timing of ontogenetic events and heterotopic-spatial expression of ontogenetic events result in evolutionary changes to the developmental program of large-versus small-beaked species of Darwin's finch.