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Calcium entry-dependent oscillations of cytoplasmic calcium concentration inclutured endothelial cell monolayers

Authors :
Laskey, R.E.
Adams, D.J.
Cannell, M.
Van Breemen, C.
Source :
Proceedings of the National Academy of Sciences of the United States. March 1, 1992, Vol. 89 Issue 5, p1690, 5 p.
Publication Year :
1992

Abstract

Agonist-induced oscillations in calcium concentrations of cultured endothelial cell monolayers were studied to determine the mechanisms involved in calcium oscillation. The results showed that thapsigargin, which inhibits bradykinin-induced calcium release, did not inhibit agonist-induced oscillations of calcium. Conversely, removal of extracellular calcium or blockage of the calcium channels immediately abolished oscillations. These results indicate that calcium concentration fluctuations are regulated by calcium entry across the plasma membrane.

Details

ISSN :
00278424
Volume :
89
Issue :
5
Database :
Gale General OneFile
Journal :
Proceedings of the National Academy of Sciences of the United States
Publication Type :
Academic Journal
Accession number :
edsgcl.13313418