Kinetic stability of Cu/Zn superoxide dismutase is dependent on its metal ligands: Implications for ALS

Authors :: Lynch, Sandra M.
Boswell, Sarah A.
Colon, Wilfredo
Source :: Biochemistry. Dec 28, 2004, Vol. 43 Issue 51, p16525, 7 p.
Publication Year :: 2004
Abstract: The kinetic stability of wild-type (WT) superoxide dismutase (SOD) and five FALS-related mutants is investigated, in both the metal-deficient (apo) and metalated (holo) forms. The important role of the metals in the kinetic stability of SOD is determined by comparing the acid-induced unfolding kinetics at physiological temperature.

Subjects :: Zinc compounds -- Chemical properties
Superoxide dismutase -- Chemical properties
Ligands (Biochemistry) -- Research
Copper compounds -- Chemical properties
Biological sciences
Chemistry

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