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Biochemical analysis of the substrate specificity of the beta-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthase

Authors :
Jiaquan Wu
Kinoshita, Kenji
Khosla, Chaitan
Cane, David E.
Source :
Biochemistry. Dec 28, 2004, Vol. 43 Issue 51, p16301, 10 p.
Publication Year :
2004

Abstract

The beta-ketoacyl-acyl carrier protein synthase (KS) domain of the modular 6-deoxyerythronolide B synthase (DEBS) catalyzes the fundamental chain building reaction of polyketide biosynthesis. The rate constants for the individual biochemical steps are determined by a combination of protein acylation and trasthioesterification experiments.

Details

Language :
English
ISSN :
00062960
Volume :
43
Issue :
51
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.132956685