Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes

Authors :: Ellison, Michael
Fan Gao
Hai-Long Wang
Sine, Steven M.
McIntosh, J. Michael
Olivera, Baldomero M.
Source :: Biochemistry. Dec 28, 2004, Vol. 43 Issue 51, p16019, 8 p.
Publication Year :: 2004
Abstract: The conus peptides alpha-conotoxin ImI (alpha-ImI) and ImII (alpha-ImII) differ by only three of 11 residues in their primary sequences and yet are shown to inhibit the human alpha7 nicotinic acetylcholine receptor (nAChR) by targeting different sites. Mutations at both faces of the classical ligand binding site of the alpha7 nAChR strongly affect antagonism by alpha-ImI but not alpha-ImII.

Subjects :: Ligand binding (Biochemistry) -- Research
Nicotinic receptors -- Chemical properties
Nicotinic receptors -- Research
Acetylcholine -- Receptors
Acetylcholine -- Chemical properties
Acetylcholine -- Research
Biological sciences
Chemistry

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