Total synthesis of (-)-kendomycin exploiting a Petasis-Ferrier rearrangement/ring-closing olefin metathesis synthetic strategy

The synthesis of (-)-kendomycin with known epoxides, aldehyde and beta-hydroxy acid (+)- is presented. Kendomycin is a novel macrocyclic polypeptide isolated from Streptomyces violaceoruber that possesses potent activity as both an endothelin receptor antagonist and an antiosteoporotic agent.