The role of chelating diamine ligands in the Goldberg reaction: A kinetic study on the copper-catalyzed amidation of aryl iodides

Authors :: Strieter, Eric R.
Blackmond, Donna G.
Buchwald, Stephen L.
Source :: Journal of the American Chemical Society. March 30, 2005, Vol. 127 Issue 12, 4120-4122
Publication Year :: 2005
Abstract: A mechanistic study identifying the role of the diamine in preventing multiple ligation of the amide is described. A copper (I) amidate that can serve as a potential intermediate during N-arylation process is also demonstrated.

Subjects :: Copper compounds -- Chemical properties
Aromatic compounds -- Chemical properties
Chemistry

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