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Solution structure of a beta-peptide ligand for hDM2
- Source :
- Journal of the American Chemical Society. March 30, 2005, Vol. 127 Issue 12, 4118-4119
- Publication Year :
- 2005
-
Abstract
- The solution structure of a beta-peptide foldamer in methanol is described. The structure reveals the details of a helix-stabilizing salt bridge on one helical face, novel 'wedge into cleft' packing along another, and distortions in the beta-peptide foldamer 14-helix that may maximize presentation of the p53 activation domain recognition epitope.
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 127
- Issue :
- 12
- Database :
- Gale General OneFile
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.132336694