Duplex molecular strands based on the 3,6-diaminopyridazine hydrogen bonding motif: Amplifying small-molecule self-assembly preferences through preorganization and iterative arrangement of binding residues

The structural parameters obtained through single-crystal X-ray diffraction analysis of the one-dimensional H-bounding motif expressed by 3,6-diaminopyridazine are applied to the design of related monomeric, dimeric, and trimeric duplex molecular strands. The results provide further insight into the structural and interactional features of synthetic duplex oligomers required for high-affinity and high-specificity binding.