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Synthesis of oligonucleotides containing Fapy.dG (N(super 6)-(2-deoxy-alpha,beta-D-erythropentofuranosyl)-2,6-diamino-4-hydroxy-5-foramidopyrimidine) using a 5'-dimethoxytrityl dinucleotide phosphoramidite
- Source :
- Journal of Organic Chemistry. Jan 7, 2005, Vol. 70 Issue 1, 141-149
- Publication Year :
- 2005
-
Abstract
- An improved method for synthesizing oligonucleotides containing Fapy.dG, which does not require reverse phosphoramidites, is described. Fapy.dG containing dinucleotide phosphoramidites containing 5'-thymidine or 5'-deoxycytidine are prepared and employed in oligonucleotide synthesis.
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 70
- Issue :
- 1
- Database :
- Gale General OneFile
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.132038715