Beta-cell antigen-specific lysis of macrophages by CD4 T-cell clones from newly diagnosed IDDM patient: a putative mechanism of T-cell-mediated autoimmune islet cell destruction

A Putative Mechanism of T-Cell--Mediated Autoimmune Islet Cell Destruction Immunophenotyping of the early lesion in the pancreatic islets of Langerhans demonstrates a predominance of [CD4.sup.+] lymphocytes, which may be preceded [...]