Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets

P-selectin, a glycoprotein, influences the congregation of leukocytes and platelets required to form a thrombus or blood clot. P-selectin is a cell adhesion molecule that controls the interaction of two types of leukocyte, monocytes and neutrophils, with platelets and endothelial cells. Experimental work with the thrombi of baboons added many details to the process by which P-selectin effects leukocyte-platelet adhesion, for instance by inducing the leukocytes to cause the formation of fibrin.