Electronic detection of single-base mismatches in DNA with ferrocene-modified probes

Authors :: C.J. Yu
Yanjian Wan
Yowanto, Handy
Jie Li
Chunlin Tao
James, Matthew D.
Blackburn, Gary F.
Meade, Thomas J.
Tan, Christine L.
Source :: Journal of the American Chemical Society. Nov 14, 2001, Vol. 123 Issue 45, p11155, 7 p.
Publication Year :: 2001
Abstract: The detection of a point mutation using dual-signaling probes on CMS-DNA arrays coupled to an electrochemical reader is described. The results show that rapid and accurate detection of a single-base mismatch is achieved by using these dual-signaling probes on CMS-DNA chips.

Subjects :: DNA probes -- Research
Mutation (Biology) -- Analysis
Mutation (Biology) -- Identification and classification
Chemistry

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