Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants

Objective. We evaluated the efficacy of probiotics in reducing the incidence and severity of necrotizing enterocolitis (NEC) in very low birth weight (VLBW) infants. Patients and Methods. A prospective, masked, randomized control trial was conducted to evaluate the beneficial effects of probiotics in reducing the incidence and severity of NEC among VLBW ( Results. Three hundred sixty-seven infants were enrolled: 180 in the study group and 187 in the control group. The demographic and clinical variables were similar in both groups. The incidence of death or NEC ([greater than or equal to] stage 2) was significantly lower in the study group (9 of 180 vs 24 of 187). The incidence of NEC ([greater than or equal to] stage 2) was also significantly lower in the study when compared with the control group (2 of 180 vs 10 of 187). There were 6 cases of severe NEC (Bell stage 3) in the control group and none in the study group. None of the positive blood culture grew Lactobacillus or Bifidobacterium species. Conclusion. Infloran as probiotics fed enterally with breast milk reduces the incidence and severity of NEC in VLBW infants. Pediatrics 2005;115:1-4; probiotics, necrotizing enterocolitis, sepsis, mortality, very low birth weight infants.
ABBREVIATIONS. NEC, necrotizing enterocolitis; VLBW, very low birth weight. Necrotizing enterocolitis (NEC) is a worldwide problem in very low birth weight (VLBW) infants, with highly variable incidence affecting 2.6% to [...]