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Uncovering novel cell cycle players through the inactivation of securin in budding yeast
- Source :
- Genetics. Nov, 2004, Vol. 168 Issue 3, p1763, 9 p.
- Publication Year :
- 2004
-
Abstract
- Budding yeast securin/Pds1p, an inhibitor of the anaphase activator separase/Esp1p, is involved in several checkpoint pathways and in promoting Esp1p's nuclear localization. Using a modified synthetic genetic array (SGA) screen for genes that become essential in the absence of Pds1p, we uncovered roles for uncharacterized genes in cell cycle processes, including Esp1p activation.
- Subjects :
- Genetics -- Research
Biological sciences
Subjects
Details
- Language :
- English
- ISSN :
- 00166731
- Volume :
- 168
- Issue :
- 3
- Database :
- Gale General OneFile
- Journal :
- Genetics
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.126851668