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A complex interaction of imprinted and maternal-effect genes modifies sex determination in odd sex (Ods) mice
- Source :
- Genetics. Nov, 2004, Vol. 168 Issue 3, p1557, 6 p.
- Publication Year :
- 2004
-
Abstract
- The transgenic insertional mouse mutation Odd Sex (Ods) represents a model for the long-range regulation of Sox9. The mutation causes complete female-to-male sex reversal by inducing a male-specific expression pattern of Sox9 in XX Ods/+ embryonic gonads. We previously described an A/J strain-specific suppressor of Ods termed Odsm[1.sup.A]. Here we show that phenotypic sex depends on a complex interaction between the suppressor and the transgene. Suppression can be achieved only if the transgene is transmitted paternally. In addition, the suppressor itself exhibits a maternal effect, suggesting that it may act on chromatin in the early embryo.
- Subjects :
- Genetics -- Research
Genetic research
Biological sciences
Subjects
Details
- Language :
- English
- ISSN :
- 00166731
- Volume :
- 168
- Issue :
- 3
- Database :
- Gale General OneFile
- Journal :
- Genetics
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.126851652