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Endurance training reduces the contraction-induced interleukin-6 mRNA expression in human skeletal muscle

Authors :
Fischer, Christian P.
Plomgaard, Peter
Hansen, Anne K.
Pilegaard, Henriette
Saltin, Bengt
Pedersen, Bente Klarlund
Source :
The American Journal of Physiology. Dec, 2004, Vol. 287 Issue 6, pE1189, 6 p.
Publication Year :
2004

Abstract

Fischer, Christian P., Peter PIomgaard, Anne K. Hansen, Henriette Pilegaard, Bengt Saltin, and Bente Klarlund Pedersen. Endurance training reduces the contraction-induced interleukin-6 mRNA expression in human skeletal muscle. Am J Phvsiol Endocrinol Metab 287: E1189-E1194, 2004. First published August 10, 2004; doi: 10.1152/ajpendo.00206.2004.--Contracting skeletal muscle expresses large amounts of IL-6. Because 1) IL-6 mRNA expression in contracting skeletal muscle is enhanced by low muscle glycogen content, and 2) IL-6 increases lipolysis and oxidation of fatty acids, we hypothesized that regular exercise training, associated with increased levels of resting muscle glycogen and enhanced capacity to oxidize fatty acids, would lead to a less-pronounced increase of skeletal muscle IL-6 mRNA in response to acute exercise. Thus, before and after 10 wk of knee extensor endurance training, skeletal muscle IL-6 mRNA expression was determined in young healthy men (n = 7) in response to 3 h of dynamic knee extensor exercise, using the same relative workload. Maximal power output, time to exhaustion during submaximal exercise, resting muscle glycogen content, and citrate synthase and 3-hydroxyacyl-CoA dehydrogenase enzyme activity were all significantly enhanced by training. IL-6 mRNA expression in resting skeletal muscle did not change in response to training. However, although absolute workload during acute exercise was 44% higher (P < 0.05) alter the training period, skeletal muscle IL-6 mRNA content increased 76-fold (P < 0.05) in response to exercise before the training period, but only 8-fold (P < 0.05, relative to rest and pretraining) in response to exercise after training. Furthermore, the exercise-induced increase of plasma IL-6 (P < 0.05, pre- and posttraining) was not higher after training despite higher absolute work intensity. In conclusion, the magnitude of the exercise-induced IL-6 mRNA expression in contracting human skeletal muscle was markedly reduced by l0 wk of training. cytokines; exercise; glycogen; plasma; skeletal muscle

Details

Language :
English
ISSN :
00029513
Volume :
287
Issue :
6
Database :
Gale General OneFile
Journal :
The American Journal of Physiology
Publication Type :
Academic Journal
Accession number :
edsgcl.126356459