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Micromechanical analysis of the binding of DNA-bending proteins HMGB1, NHP6A, and HU reveals their ability to form highly stable DNA-protein complexes

Authors :
Dunja Skoko
Ben Wong
Johnson, Reid C.
Marko, John F.
Source :
Biochemistry. Nov 2, 2004, Vol. 43 Issue 43, 13867-13874
Publication Year :
2004

Abstract

Micromechanical analysis of the binding of DNA-bending proteins HMGB1, NHP6A, and HU is investigated using DNA micromanipulation. The results show that the stability of the DNA-protein complexes is dependent on the protein concentration during the binding.

Details

Language :
English
ISSN :
00062960
Volume :
43
Issue :
43
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.125756894