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The cloning of a family of genes that encode the melanocortin receptors
- Source :
- Science. August 28, 1992, Vol. 257 Issue 5074, p1248, 4 p.
- Publication Year :
- 1992
-
Abstract
- Melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) regulate pigmentation and adrenal cortical function, respectively. These peptides also have a variety of biological activities in other areas, including the brain, the pituitary, and the immune system. A complete understanding of the biological activities of these hormones requires the isolation and characterization of their corresponding receptors. The murine and human MSH receptors (MSH-Rs) and a human ACTH receptor (ACTH-R) were cloned. These receptors define a subfamily of receptors coupled to guanine nucleotide-binding proteins that may include the cannabinoid receptor.<br />Proopiomelanocortin (POMC) is expressed primarily in the pituitary and in limited regions in the brain and periphery. It is processed into a large and complex family of peptides with an [...]
Details
- Language :
- English
- ISSN :
- 00368075
- Volume :
- 257
- Issue :
- 5074
- Database :
- Gale General OneFile
- Journal :
- Science
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.12561342