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Alpha-alkylation of ketones by addition of zinc enamides to unactivated olefins
- Source :
- Journal of the American Chemical Society. Sept 29, 2004, Vol. 126 Issue 38, p11820, 6 p.
- Publication Year :
- 2004
-
Abstract
- A zinc enamide generated from the corresponding N-aryl imine undergoes addition to an unactivated olefin, to generate an alpha-alkylated gamma-zincioimine intermediate in good to excellent yield. The organozinc intermediate undergoes further C-C bond formation with a carbon electrophile to give, upon hydrolysis of the imine, an alpha-alkylated ketone.
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 126
- Issue :
- 38
- Database :
- Gale General OneFile
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.125312576