Fabrication of assembled virus nanostructure on templates of chemoselective linkers formed by scanning probe nanolithography

A multistep approach to biomolecular assembly is presented, which combines scanning probe nanolithography (SPN) with chemoselective protein-to-surface linkers to create nanometric chemical templates for fabricating virus arrays. The assembly of these arrays introduces unique target chemical groups on the virus surface and design a chemoselective linker and reaction scheme to covalently bind the virus onto a patterned chemical template created by SPN.