X-ray crystal structure of the hypothetical phosphotyrosine phosphtase MDP-1 of the haloacid dehalogenase superfamily

Haloacid dehalogenase (HAD) superfamily mainly consists of structurally homologous enzymes, which have several conserved sequence motifs in their active site. HAD can be divided into three sub-classes, based on the domain organization. Studies and observations showing that the target of magnesium dependent phosphate-1 (MDP-1) is a phosphotyrosine in an unknown protein and not a sugar based substrate are explained.